10 Clary Sage Essential Oil Health Benefits

The foundation of women’s health remedies, clary sage essential oil benefits both men and women. It’s calming, healing, and very safe to use, but it does come with some potential risks. Learning how to properly use this ancient remedy is pretty straightforward and important to know!

What is Clary Sage?

To learn about the benefits of clary sage essential oil, let’s learn more about this plant. The medicinal use of clary sage dates back to the age of Rome and Greece. Officially named Salvia sclarea, it was used for eye conditions, to clear (clarify) the eyes, potentially with the mucilaginous seeds. In 1653, Dante Culpeper’s work Complete Herbal described clary sage as such:

“The seed put into the eyes clears them from motes, and such like things gotten within the lids to offend them, as also clears them from white and red spots on them. The mucilage of the seed made with water, and applied to tumors, or swellings, disperses and takes them away; as also draws forth splinters, thorns, or other things have gotten into the flesh. The leaves used with vinegar, either by itself, or with a little honey, doth help boils, felons, and the hot inflammation that are gathered by their pains, if applied before it be grown too great… The juice of the herb put into ale or beer, and drank, brings down women’s courses, and expels the after-birth.”  (1)

Centuries later, we still embrace the benefits of clary sage essential oil in similar ways, with particular focus on its anti-inflammatory benefits and role in women’s health.

Primarily originating from the Mediterranean region, clary sage is a species in the Salvia genus, which you may know from your ornamental perennial garden or from its cousin sage, which is used for both culinary and medicinal purposes. The Salvia genus is a part of the larger Lamiaceae distinction, where we also find our mint varieties, which is full of fragrant plants rich in essential oil and healing qualities.

Clary sage is used in both herb and essential oil forms, and even the seeds have nutritional value. As with any herb or essential oil, where clary sage is grown, how and when it is harvested, and the parts of the plant used all play a part in the quality and components.

Covered in spikes of flowers, fragrant, and grown as a perennial, it’s little wonder that the ancients found use for this favorite family of herbs!

Composition of Clary Sage

Clary sage essential oil is derived from the flowering tops and contains many components known for their anti-inflammatory and calming benefits, including linalool (a major component of lavender essential oil), linalyl acetate (excellent for anti-inflammatory benefits on the skin), and a minor component called sclareol. The method of extraction may affect the components found in the essential oil, so always be aware of your source before using an oil therapeutically.

Aside from anti-inflammatory abilities, clary sage is also known to be relaxing and antidepressant, making it useful for stress relief, sleep aid, and more. It’s also shown to be antifungal and antimicrobial.

Another component, sclareol, has shown some promising things in lab tests. Over the last couple of decades but as recently as this year (2015), studies have emerged that analyze sclareol’s effect on cancer cells. With the caveat that these benefits occurred within the confines of lab cultures and dose adjustments, sclareol may have an impact on the way that cancer cells proliferate, and they could help to induce apoptosis (cancer cell death). (2)

More About Essential Oils and Cancer Read more about essential oils and cancer to see what the research is showing!

While this does not tell us how much potential sclareol has to directly treat cancer – it’s exciting to think about where that could go one day! – it is a common thread that we see in many antioxidant-rich essential oils. This is especially interesting for clary sage because some claim that it is “estrogenic” due to the sclareol content and should be avoided by estrogen-dominant cancer patients. This, of course, is a myth and I discuss the reasons why at the end of this report.

10 Ways Clary Sage Can Help with Chronic Disease

Clary sage essential oil has been revered for centuries for its therapeutic benefits, and modern science is now catching up to confirm its role in chronic disease management. From hormonal balance to neuroprotection, this aromatic oil is proving to be a natural ally for those dealing with long-term health conditions. Below, we explore the top 10 scientifically supported ways clary sage can improve well-being and help combat chronic diseases.

1. Anti-Inflammatory Effects for Chronic Conditions

Chronic inflammation is a major contributor to diseases such as arthritis, autoimmune disorders, and metabolic syndrome. Clary sage contains powerful compounds like linalool and linalyl acetate, which have been shown to reduce inflammatory markers in the body. Research has demonstrated that clary sage essential oil can help regulate the body’s immune response and decrease oxidative stress, two factors that play a significant role in chronic disease development. By supporting the body’s natural ability to manage inflammation, clary sage may provide relief for those suffering from long-term inflammatory conditions.

2. Cancer Support and Tumor Reduction

The compounds in clary sage, particularly sclareol, have shown potential in cancer research. Sclareol has been studied for its ability to trigger apoptosis, a process that leads to the natural death of cancer cells. Some studies indicate that when used alongside chemotherapy drugs, clary sage may enhance their effectiveness by making tumor cells more responsive to treatment. Its ability to promote mitochondrial-mediated cell death suggests that it may be a useful complementary approach for individuals undergoing cancer therapies.

3. Mood Enhancement and Dopamine Regulation

Dopamine imbalances are linked to mood disorders such as depression and anxiety. Clary sage has been studied for its effects on neurotransmitter activity, particularly its ability to regulate dopamine and serotonin levels. In aromatherapy, it is often used to alleviate symptoms of anxiety, stress, and emotional fatigue. Its calming properties help promote relaxation and mental clarity, making it a useful tool for those managing stress-related mood disorders. When combined with essential oils like lavender and bergamot, it creates an even more powerful effect on emotional well-being.

4. Cardiovascular Health and Blood Pressure Regulation

Hypertension is a major risk factor for stroke, heart disease, and kidney failure. Clary sage has been found to have hypotensive properties, meaning it can help lower blood pressure naturally. Studies suggest that inhaling clary sage oil may reduce systolic blood pressure and heart rate, likely due to its relaxing effects on the nervous system. By supporting healthy circulation and reducing stress-related hypertension, clary sage offers a natural and effective way to promote cardiovascular wellness.

5. Natural Pain Relief

Chronic pain conditions such as fibromyalgia, arthritis, and migraines can be difficult to manage with conventional medicine alone. Clary sage has analgesic and anti-spasmodic properties that make it an excellent natural pain reliever. Research shows that when applied topically with carrier oils or used in aromatherapy, clary sage can reduce muscle spasms, joint discomfort, and tension headaches. Many pain relief blends include clary sage along with lavender and frankincense for added anti-inflammatory benefits.

6. Neuroprotective Benefits for Alzheimer’s and Cognitive Decline

As neurodegenerative diseases like Alzheimer’s and Parkinson’s continue to rise, interest in natural cognitive support is increasing. Clary sage contains compounds that help protect neurons from oxidative stress and reduce the accumulation of harmful proteins in the brain. Some studies suggest that regular inhalation of clary sage essential oil may enhance cognitive function and improve memory retention. Its potential to reduce stress and anxiety also contributes to brain health, as chronic stress is a known risk factor for cognitive decline.

7. Respiratory Health and Chronic Lung Inflammation

Chronic respiratory diseases such as asthma, COPD, and bronchitis often involve inflammation and excessive mucus production in the lungs. Clary sage has expectorant and anti-spasmodic properties that help open airways and reduce congestion. Research suggests that diffusing clary sage essential oil or using it in steam inhalation can support lung function by clearing mucus and reducing inflammation in the respiratory tract. Many people incorporate clary sage into respiratory blends alongside eucalyptus and peppermint for enhanced effects.

8. Stress Reduction and Cortisol Management

Chronic stress is a major contributor to disease, weakening the immune system and increasing the risk of conditions like hypertension, diabetes, and autoimmune disorders. Clary sage has been found to help regulate cortisol, the body’s primary stress hormone. Inhaling clary sage oil has been shown to promote relaxation, lower blood pressure, and improve overall mood. Its ability to reduce physiological stress makes it an excellent natural tool for managing chronic stress and preventing the long-term health effects associated with it.

9. Skin Health and Anti-Aging Properties

Clary sage contains antioxidants and antimicrobial compounds that support skin health. Inflammatory skin conditions such as eczema, rosacea, and psoriasis often result from chronic inflammation and oxidative stress. Studies indicate that sclareol, a compound in clary sage, helps reduce inflammation and supports collagen production, which can improve skin elasticity and reduce the appearance of fine lines and wrinkles. Many natural skincare products incorporate clary sage for its ability to promote a clear, healthy complexion while soothing irritation and redness.

10. Hormonal Balance for Menopause and Women’s Health

Clary sage has natural phytoestrogenic properties, meaning it can mimic estrogen in the body and help regulate hormonal fluctuations. This makes it particularly beneficial for women experiencing menopause, menstrual irregularities, or hormonal imbalances. Studies have shown that inhaling clary sage essential oil can significantly reduce cortisol levels while increasing serotonin, promoting a sense of well-being. Many women use clary sage to alleviate symptoms such as hot flashes, mood swings, and menstrual discomfort, making it a natural alternative to hormone replacement therapy.

Special Note About Women’s Health

Clary sage is most commonly known as an herb and essential oil for women’s health issues, exhibiting benefits in all phases of life. Young women dealing with menstrual pain have found relief, even more so than what acetaminophen could provide. Women with dysmenorrhea found similar relief. This study used aromatherapy in conjunction with massage.

In childbirth, where pain is often exacerbated by anxiety and stress, clary sage and chamomile exhibit strong pain relieving results in a safe, easily administered manner. In fact, when a midwifery practice implemented the use of these oils both topically in a carrier oil and via diffusion, there appeared to be a reduction in the use of opioid medications.

Finally, as women reach menopausal years, the use of antidepressants begins to increase dramatically. Clary sage may help to ease this stressful transition of life, reducing cortisol levels and exhibiting an antidepressant-like effect See more essential oils for menopause here.

For maximum effects, try blending clary sage with oils that have similar properties, like lavender essential oil or chamomile essential oil.

Try One or More of These Recipes Using Clary Sage Essential Oil

• Hormone Balancing Essential Oil Serum
• Homemade Body Powder with Essential Oils DIY
• Homemade Cream for Breastfeeding
• Homemade Essential Oil Perfume Roll-On
• Essential Oil Sleep Spray

These are just a handful of the marvelous ways you can use clary sage essential oil in your life!

Is Clary Sage Oil Estrogenic?

The simple answer is, “No.”

There is a myth floating around the cyber world that because clary sage contains sclareol, it mimics the steroid estrogen, but this is simply a poor understanding of the science of phytochemicals. Chemist Robert Pappas, PhD explains it best:

• “First of all sclareol is actually a very minute component of the essential oil of clary sage despite some authors claiming that sclareol is present in clary sage oil at 1.6-7.0%, an utterly ridiculous claim. Almost all steam-distilled clary sage oils on the market (I would say 99.9% of them) have less than 0.5% sclareol content….
• “Secondly, if we look at the structure of sclareol…we will see that it actually has very little in common with the structure of any of the estrogen molecules…Sclareol is not a steroid but what would have to be termed a diterpene diol, not even remotely close to the necessary steroidal backbone.”
• “Sclareol is not a steroidal estrogen, does not mimic the function of any estrogen molecules, does not stimulate estrogen production (why would it?), and would not appear to have any mechanism by which it can “balance hormones” at least not by a pathway that has anything to do with estrogens… I am not saying that it’s impossible that clary sage can have some of the effects that have been claimed, but just be aware that it’s not really possible that the oil can mimic estrogens or that the oil contains estrogen-like molecules.”

In regard to estrogenic breast cancer, essential oil expert Robert Tisserand mimics Pappas’ assertion, “Sclareol does have an interesting anticancer activity, including in vitro action against human breast cancer MCF-7 cells (Dimas et al 2006). An isomer, 13-epi-sclareol, which is also present in clary sage oil, inhibits the growth of breast and uterine cancers in vitro, and was slightly more potent than Tamoxifen, but was not toxic to normal cells (Sashidhara et al 2007). This suggests the possibility that sclareol might actually inhibit estrogen, and might after all have some capacity to interact with estrogen receptor sites. What we do know is that sclareol will not give you breast cancer.”

Clary sage is more than just a fragrant essential oil—it is a powerful tool for chronic disease management. From reducing inflammation and balancing hormones to improving mood and protecting cognitive function, its scientifically backed benefits make it a valuable addition to any natural wellness routine. Whether used in aromatherapy, applied topically, or blended with other essential oils, clary sage provides a gentle yet effective approach to long-term health. Have you tried clary sage? Let us know!

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